University of Pennsylvania: School of Veterinary Medicine - Department of Clinical Studies, Philadelphia

The following table outlines the main contents of the metabolic screening program in the Section of Medical Genetics.

ABNORMAL METABOLITES IN URINE OF SMALL ANIMALS WITH TYPICAL INBORN ERRORS OF METABOLISM
Urinary Amino Acids	Name of Disorder	Species or Breed
Increased
Generalized	Fanconi syndrome	Basenji and others
Cystine	Cystinuria	Many breeds
Ornithine	Ornithine aminotransferase deficiency	Domestic short hair cats
Ornithine	Gyrate atrophy
Tyrosine	Tyrosine aminotrasferase deficiency	German shepherd
Tyrosine	Tyrosinemia type II
Citrulline	Argininosuccinate synthetase deficiency	Golden retriever, Beagle
Sarcosine	Hypersarcosinemia	Portuguese water dogs
Alanine, glutamine	Portosystemic shunts	Many breeds of dogs and cats
Alanine, glutamine	Liver disease	Many breeds of dogs and cats
Glycine, alanine, protein		Sheltie, Collie
Decreased
Taurine	Taurine deficiency (cardiac disease and retinal atrophy)	Cats
Felinine	"Sick" cat, malnutrition	Cats
Urinary Organic Acids	Name of Disorder	Species or Breed
Methylmalonic acid	Selective cobalamin intestinal malabsorption (Vitamin B12 deficiency)	Giant schnauzers, Border collie, Beagle, cats
Methylmalonic acid	Methylmalonic aciduria	Shar pei, Basset hound
Lactic acid	Lactic acidosis	Irish setter, other dogs and cats
	Mitochondrial myopathy	Old English sheepdogs
	Fanconi syndrome	Basenji, Norwegian elkhound
Isovaleric acid	Isovaeric aciduria	Siamese
Oxalate, L-glycerate	Primary hyperoxluria	Cats, Tibetan spaniel
Urinary Carbohydrates	Name of Disorder	Species or Breed
Glucose	Diabetes mellitus	Dogs, cats
	Renal glucosuria	Norwegian elkhounds
	Fanconi syndrome	Basenji, others
Lactose	Lactosuria	Nursing animals
Lactose	Liver disease	Dogs, cats
Galactose	Liver disease	Dogs
Urinary Glycosaminoglycans	Name of Disorder	Species or Breed
Dermatan sulfate	MPS I	Domestic cats, Plotthound dogs, Rottweiler
	MPS II	Labrador retriever dogs
	MPS VI	Siamese cats, Domestic short hair cats
		Miniature pinscher dogs, Welsh corgi dogs
	MPS VII	Mix-breed dogs, German shepherd and Domestic short hair cats
Heparan sulfate	MPS IIIA	Wirehaired dachshund dogs
Heparan sulfate	MPS IIIB	Skiperkee, Emus (avian)
Chondroitin sulfate	Rapid growth, Hypothyroidism, Various dwarfism, Metabolic bone disease	Dogs, cats
Urinary Oligosaccharides	Name of Disorder	Species or Breed
Variety of mannose- containing oligosaccharides	Mannosidosis	Cats
High molecular weight-oligosaccharides	GM1 gangliosidosis	Dogs and cats
	GM2 gangliosidosis	Dogs and cats
	Fucosidosis	English Springer spaniels