Metabolic Screening Submission Form
About Metabolic Screening

Description:
The Fanconi syndrome indicates a generalized defect in amino acid reabsorption in the kidney, but often refers to a more general renal tubular transport defect leading to progressive renal disease. Fanconi syndrome is well recognized in Basenjis and has been seen in other canine breeds with increased frequency, but may be also be acquired. Hereditary defects may cause signs by a few years of age and are progressive leading to death within a few years, whereas acquired forms may be reversable. The mode of inheritance and specific nature of the hereditary defects have not yet been identified.

Fanconi syndrome may be suspected in animals having glucosuria despite a normal blood glucose level (no diabetes mellitus) with or without renal failure. Further clinical diagnostic tests may indicate abnormal clearance of sodium and phosphate. The Metabolic Genetic Disease Testing Laboratory of the School of Veterinary Medicine at the University of Pennsylvania can screen for generalized amino aciduria and lactic aciduria.

Affected Breeds:
Basenji
Norwegian Elkhound
Other Breeds

Required Samples:
Urine in a plastic vial, 5 mL

Price: $30 each